Disintegrin



Disintegrins are a family of toxins from viper venoms which inhibit platelet aggregation and cell adhesion. The images at the left and at the right correspond to one representative Disintegrin, i.e. the crystal structure of Disintegrin from Echis carinatus (1z1x).

3D Structures of Disintegrin
2w9o, 2w9u, 2w9v, 2w9w – jerdostatin residues 68-110 – Trimeresurus jerdonii – NMR

1j2l – trimestatin - Trimeresurus flavovidrius

2pjf, 1q7i, 1q7j – Cr rhodostoxin residues 1-68 – Calloselasma rhodostoma – NMR

2pjg, 2pji - Cr rhodostoxin (mutant) – NMR

1z1x, 1tej – Ec disintegrin – Echis carinatus

1rmr – Ec schistatin

1ro3, 2ech – Ec echistatin - NMR

1l3x – salmosin – Gloydius brevicaudus – NMR

1mpz – obtustatin – Macrovipera obtusa - NMR

1dem – dendrotoxin I – black mamba

1den - dendrotoxin I - NMR

1dtk - dendrotoxin K- NMR

1dtx – α-dendrotoxin - Eastern green mamba

3c05 – acostatin-α residues 48-109+acostatin-β residues 419-482 – copperhead

3dsl – bothropasin - Jararaca